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KMID : 1100720150350010132
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Annals of Laboratory Medicine
2015 Volume.35 No. 1 p.132 ~ p.136
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Clinical Relevance of High-Resolution Single Nucleotide Polymorphism Array in Patients with Relapsed Acute Lymphoblastic Leukemia with Normal Karyotype: A Report of Three Cases
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Park Sang-Hyuk
Lee Seung-Hee
Kim Shine-Young
Lee Sun-Min
Yi Jong-Youn
Kim In-Suk
Kim Hyung-Hoi
Chang Chulhun L
Lee Eun-Yup
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Abstract
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We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated the clinical relevance of the SNP-A assay for the detection of subtle changes in the size of affected genetic lesions at relapse as well as the prognostic value of the assay. In our patients, application of the SNP-A assay enabled sensitive detection of cryptic changes affecting clinically important genes in NK ALL. Therefore, this assay seems to be more advantageous compared to other conventional methods such as FISH assay, HemaVision (DNA Technology, Denmark), and conventional karyotyping for the detection of an “unstable genotype” at relapse, which may be associated with microscopic clonal evolution and poor prognosis. Further comprehensive studies are required to confirm the issues presented by our case patients in this report.
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KEYWORD
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Acute lymphoblastic leukemia, Array, Clonal evolution, Normal karyotype, Prognosis, Single nucleotide polymorphism
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